Know Your Blood Parameters: Lipase
- Summarised by TGHC Editorial Team
- Aug 9, 2025
- 3 min read
Updated: Dec 9, 2025
Parameter Name
Lipase
Lipase is an enzyme that plays a crucial role in the digestive process, specifically in the breakdown of dietary fats into smaller molecules that can be easily absorbed by the body. It is produced primarily in the pancreas, but small amounts are also secreted by the stomach and the intestines.
Test Type
Blood
The lipase test is a blood test that measures the level of lipase enzyme in the bloodstream. It is commonly performed as part of a panel of tests to assess pancreatic function and diagnose potential pancreatic disorders. The blood sample is typically drawn from a vein in the arm and sent to a laboratory for analysis.
Normal Range
10–140 U/L (lab-specific ranges may vary)
The normal range for lipase levels can vary slightly depending on the laboratory conducting the test. It is important to note that different labs may use different methods for measuring lipase, which can result in variations in the reference ranges. Therefore, it is essential to interpret the results in the context of the specific laboratory's reference values.
High Levels Indicate
Acute pancreatitis, pancreatic cancer, bowel obstruction, or kidney disease.
Elevated levels of lipase in the blood can indicate several serious conditions. Acute pancreatitis, which is inflammation of the pancreas, is the most common reason for elevated lipase levels. Other potential causes include pancreatic cancer, which may block the normal flow of digestive enzymes, leading to increased lipase levels. Additionally, bowel obstruction can cause a backup of digestive enzymes, and kidney disease can impair the clearance of lipase from the bloodstream, resulting in higher concentrations.
Low Levels Indicate
Permanent pancreatic damage, chronic pancreatitis, or cystic fibrosis.
Conversely, low levels of lipase can be indicative of underlying health issues as well. Conditions such as permanent pancreatic damage, often resulting from chronic pancreatitis, can lead to decreased production of lipase. Cystic fibrosis, a genetic disorder that affects the lungs and digestive system, can also result in low lipase levels due to the thick mucus that obstructs the pancreatic ducts, preventing the enzyme from reaching the intestines.
Why It's Tested
More specific than amylase for diagnosing acute pancreatitis.
The lipase test is particularly valuable because it is more specific for pancreatic disorders than other tests, such as amylase. While amylase can be elevated in various conditions, lipase is more closely associated with pancreatic function. This specificity makes the lipase test a preferred choice for diagnosing acute pancreatitis, allowing healthcare providers to make more accurate assessments and treatment decisions.
Associated Symptoms (if abnormal)
Severe upper abdominal pain, nausea, vomiting, fever when the levels are high & signs of fat malabsorption when low.
When lipase levels are elevated, patients may experience severe upper abdominal pain, which can radiate to the back. Accompanying symptoms often include nausea and vomiting, and in some cases, fever may be present, indicating inflammation or infection. In contrast, low lipase levels can lead to symptoms related to fat malabsorption, such as steatorrhea (fatty stools), weight loss, and deficiencies in fat-soluble vitamins (A, D, E, K), which can further complicate the patient's nutritional status.
What To Do If Abnormal
Repeat testing if needed, use imaging, manage with supportive care and treat cause.
If lipase levels are found to be abnormal, it is important to take further steps to determine the underlying cause. This may include repeating the test to confirm the initial results, as well as utilizing imaging studies such as ultrasound or CT scans to visualize the pancreas and surrounding structures. Management typically involves supportive care, which may include pain management, hydration, and nutritional support, while addressing the root cause of the abnormal lipase levels through appropriate medical or surgical interventions.
Common Conditions Related
Acute pancreatitis, chronic pancreatitis, pancreatic cancer.
Several common medical conditions are closely associated with abnormal lipase levels. Acute pancreatitis, characterized by sudden inflammation of the pancreas, is the most frequent condition linked to high lipase levels. Chronic pancreatitis, which is a long-standing inflammation that can lead to permanent damage, is another significant condition. Additionally, pancreatic cancer can present with elevated lipase levels, particularly in advanced stages when the tumor obstructs pancreatic function.
Nutrition or Lifestyle Connection
Avoid alcohol, eat low-fat meals, monitor fat-soluble vitamin intake if chronic.
There is a notable connection between nutrition, lifestyle choices, and pancreatic health. For individuals with chronic pancreatitis or pancreatic insufficiency, it is crucial to avoid alcohol, as it can exacerbate inflammation and further damage pancreatic tissue. Additionally, adopting a low-fat diet can help minimize the workload on the pancreas, allowing for better management of symptoms. Furthermore, those with chronic conditions should be vigilant about their intake of fat-soluble vitamins, as malabsorption can lead to deficiencies that require supplementation to maintain overall health and well-being.
References (APA Format)
MedlinePlus. (2023). Lipase blood test.
American Gastroenterological Association. (2022).
