Know Your Blood Parameter: eGFR
- Summarised by TGHC Editorial Team
- Jun 23, 2025
- 3 min read
Updated: Dec 29, 2025
Parameter Name
eGFR (Estimated Glomerular Filtration Rate)
The eGFR is a crucial measurement used to assess kidney function by estimating how well the kidneys are filtering waste from the blood. This parameter is derived from various factors including serum creatinine levels, age, gender, and race, thereby providing a comprehensive view of kidney health.
Test Type
Blood (calculated from creatinine)
The eGFR test is primarily conducted on a blood sample where the level of creatinine, a waste product generated from muscle metabolism, is measured. This value is then applied in a formula that factors in the patient’s demographic information to yield the eGFR result.
Normal Range
≥ 90 mL/min/1.73 m² (with no kidney damage).
A normal eGFR indicates that the kidneys are functioning properly, efficiently filtering blood, and that there is no significant kidney damage. Values above this threshold signify optimal kidney health, while consistent readings in this range are essential for monitoring individuals at risk of kidney disease.
High Levels Indicate
Not clinically relevant (may reflect overestimation in muscle wasting).
Elevated eGFR levels are generally not a cause for concern; however, they may suggest inaccuracies due to conditions such as muscle wasting or low muscle mass, which can lead to an overestimation of kidney function. It is important for healthcare providers to interpret these values in the context of the patient's overall health and physical condition.
Low Levels Indicate
Reduced kidney filtration, indicating CKD stages 1–5 based on value.
Low eGFR levels are indicative of reduced kidney function and can signify chronic kidney disease (CKD). The stages of CKD are categorized based on eGFR values, with lower values indicating more advanced stages of the disease, which require closer monitoring and management to prevent further deterioration of kidney health.
Why It's Tested
Best marker to evaluate kidney function and classify CKD stages.
The eGFR test is considered the gold standard for evaluating kidney function. It plays a pivotal role in the early detection of kidney disease, allowing for timely interventions that can slow disease progression. Furthermore, it assists healthcare providers in determining the appropriate treatment plans and monitoring the effectiveness of interventions over time.
Associated Symptoms (if abnormal)
Often silent; may show fatigue, edema, nausea in later stages.
Abnormal eGFR levels can often present without noticeable symptoms, making regular testing essential for early detection. However, as kidney function declines, patients may experience symptoms such as persistent fatigue, swelling (edema), nausea, and changes in urination patterns. These symptoms often manifest in the later stages of kidney disease, emphasizing the importance of proactive monitoring.
What To Do If Abnormal
Monitor trends, control BP/sugar, consult nephrologist if < 60 mL/min.
If eGFR results are abnormal, it is crucial to monitor kidney function over time to identify trends. Patients should also focus on managing blood pressure and blood sugar levels, as these factors significantly impact kidney health. If eGFR falls below 60 mL/min, it is advisable to consult a nephrologist for specialized care and to explore potential treatment options.
Common Conditions Related
CKD, diabetes-related nephropathy, hypertension
Several health conditions are closely associated with abnormal eGFR levels. Chronic kidney disease (CKD) is the most prevalent, but diabetes-related nephropathy and hypertension are also significant contributors to kidney dysfunction. Understanding these associations can aid in the prevention and management of kidney-related health issues.
Nutrition or Lifestyle Connection
Low-sodium, renal-friendly diet, protein moderation, stay active.
Diet and lifestyle choices play a critical role in maintaining kidney health and can influence eGFR levels. A renal-friendly diet that is low in sodium and moderate in protein can help reduce the workload on the kidneys. Additionally, staying active through regular exercise promotes overall health and can support kidney function. Adopting these lifestyle changes is essential for individuals at risk of or currently experiencing kidney issues.
References (APA Format)
National Kidney Foundation. (2023). eGFR guidelines.
MedlinePlus. (2023). eGFR test.
KDIGO Guidelines. (2022). CKD evaluation and management.
